SciBeh-Topic-Visualization

vaccine, trial, approve, drug, healthy

Topic 10

vaccine trial approve drug healthy interim volunteer therapy moderna novavax pharma russia halt pfizer race

Covid-19 vaccine from Pfizer and BioNTech shows positive results
July 1, 2020 · · Original resource · news

An experimental Covid-19 vaccine being developed by the drug giant Pfizer and the biotech firm BioNTech spurred immune responses in healthy patients, but also caused fever and other side effects, especially at higher doses.The first clinical data on the vaccine were disclosed Wednesday in a paper released on MedRXiv, a preprint server, meaning it has not yet been peer-reviewed or published in a journal. 
covid-19
clinical trial
vaccine
development
immunity
epidemiology
research
vaccine, trial, approve, drug, healthy
protein, spike, neutralize, ace2, design
‘Just beautiful’: Another COVID-19 vaccine, from newcomer Moderna, succeeds in large-scale trial
Nov. 16, 2020 · · Original resource · webpage

Another COVID-19 vaccine using the same previously unproven technology as the vaccine from Pfizer and BioNTech, the U.S. and German companies that reported success on 9 November, appears to work remarkably well. And this time, the maker, U.S. biotech Moderna, is releasing a bit more data to back its claim than the other two companies.
covid-19
trial
vaccine
efficacy
usa
distribution
health
moderna
pfizer
optimism
vaccine, trial, approve, drug, healthy
herd, immunity, far, hope, know
Expecting the unexpected with COVID-19 vaccines

Global efforts for development of a COVID-19 vaccine are yielding multiple results including some new and as yet unlicensed technologies.1Le TT Cramer JP Chen R Mayhew S Evolution of the COVID-19 vaccine development landscape.Nat Rev Drug Discov. 2020; 19: 667-668Crossref PubMed Scopus (17) Google Scholar Reception of these vaccine candidates by a skeptical public will challenge wide acceptance of new vaccines. Regulatory safety thresholds are a minimum bar that a product must pass to attain regulatory approval, but for the general public, cumulative safety experience will be important. Trust is earned with time, and with repeated experience. Vaccines have a long safety history, but COVID-19 vaccines are new. In this context, Yanjun Zhang and colleagues' report of their phase 1/2 trial of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in The Lancet Infectious Diseases is instructive.2Zhang Y Zheng G Pan H et al.Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial.Lancet Infect Dis. 2020; (published online Nov 17.)https://doi.org/10.1016/S1473-3099(20)30843-4Google Scholar
covid-19
trial
vaccine
infection
public health
vaccine, trial, approve, drug, healthy
herd, immunity, far, hope, know
WHO looks at giving Covid-19 to healthy people to speed up vaccine trials
Dec. 7, 2020 · · Original resource · news

The World Health Organization is holding discussions on Monday about the feasibility of trials in which healthy young volunteers are deliberately infected with coronavirus to hasten vaccine development – amid questions over whether they should go ahead given the promising data from the frontrunner vaccine candidates.
covid-19
vaccine
who
risk
research
exposure
benefit
vaccine, trial, approve, drug, healthy
herd, immunity, far, hope, know
The UK has approved a COVID vaccine — here’s what scientists now want to know
Dec. 3, 2020 · · Original resource · news

The Pfizer–BioNTech vaccine has passed safety and efficacy tests — but researchers still have many questions about how this and other vaccines will perform as they’re rolled out to millions of people.
covid-19
clinical trial
vaccine
safety
uk
efficacy
transmission
approval
research
vaccine, trial, approve, drug, healthy
herd, immunity, far, hope, know
Analysis supports phase 3 trials of Johnson & Johnson's COVID-19 vaccine
Jan. 17, 2021 · · Original resource · news

Researchers in the Netherlands, the United States, and Belgium have presented early-stage clinical trial results demonstrating the safety and efficacy of Johnson & Johnson's vaccine candidate for coronavirus disease 2019 (COVID-19). Phase 1–2a interim results show that the vaccine is safe and immunogenic in both younger and older adults after just a single dose, thereby supporting evaluation in phase 3 trials.
covid-19
clinical trial
vaccine
safety
efficacy
analysis
result
vaccine, trial, approve, drug, healthy
protein, spike, neutralize, ace2, design
Will Kids Get A COVID-19 Vaccine? Pfizer To Expand Trial To Ages 12 And Up
Oct. 13, 2020 · · Original resource · news

Pfizer announced this week that it has received FDA approval to enroll children as young as 12 years old in its COVID-19 vaccine trial. The expansion is aimed at understanding whether the vaccine would be safe and effective for adolescents.
covid-19
vaccine
usa
adolescent
immune response
vaccine, trial, approve, drug, healthy
library, open, preservation, psa, tool
Coronavirus Vaccine U.K. Trial Restarts, But Scientists Question Lack of Transparency
Sept. 14, 2020 · · Original resource · news

UK trials of the Oxford and AstraZeneca vaccine have resumed after a brief pause, yet key details of the events have not been released
covid-19
clinical trial
communication
uk
transparency
research
criticism
vaccine development
pharmaceutical
vaccine, trial, approve, drug, healthy
herd, immunity, far, hope, know
The Long Haul of Vaccine Results Is Just Beginning
Dec. 1, 2020 · · Original resource · news

The initial results of the AstraZeneca/Oxford vaccine trials were unexpected and confusing, but there’s more data to come.
covid-19
trial
vaccine
efficacy
data
error
result
oxford
manufacture
vaccine, trial, approve, drug, healthy
herd, immunity, far, hope, know
Oxford's Covid-19 vaccine appears safe and induces immune response, early results suggest, but more research is needed
July 21, 2020 · · Original resource · news

Results from trials involving three different coronavirus vaccines released Monday, all showing positive results, with evidence the vaccines can produce immune responses that would be expected to protect people against infection.They all also appeared to be safe, although it will take studies with more people to show how safe they really are and whether they can prevent infection.
covid-19
clinical trial
safety
protection
epidemiology
immune response
research
vaccine development
preliminary findings
vaccine, trial, approve, drug, healthy
herd, immunity, far, hope, know